2026-04-29T15:24:43Zhttps://repisalud.isciii.es/rest/oai/request
oai:repisalud.isciii.es:20.500.12105/181042024-02-12T19:47:05Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud author Guerrero-Orriach, Jose L author Malo-Manso, Alfredo author Ramirez-Aliaga, Marta author Florez Vela, Ana Isabel author Galán-Ortega, Manuel author Moreno-Cortes, Isabel author Gonzalez-Almendros, Inmaculada author Ramirez-Fernandez, Alicia author Ariza-Villanueva, Daniel author Escalona-Belmonte, Juan Jose author Quesada-Muñoz, Guillermo author Sepúlveda-Haro, Enrique author Romero-Molina, Salvador author Bellido-Estevez, Inmaculada author Gomez-Luque, Aurelio author Rubio-Navarro, Manuel author Alcaide-Torres, Juan author Santiago-Fernandez, Concepcion author Garrido-Sanchez, Lourdes author Cruz-Mañas, Jose 2024-02-12T19:47:05Z 2024-02-12T19:47:05Z 2020-08-26 10.3389/fphar.2020.01331 1663-9812 Frontiers in pharmacology http://hdl.handle.net/10668/16327 32982742 http://hdl.handle.net/20.500.12105/18104 Low-cardiac output syndrome (LCOS) after cardiac surgery secondary to systemic hypoperfusion is associated with a higher incidence of renal and neurological damage. A range of effective therapies are available for LCOS. The beneficial systemic effects of levosimendan persist even after cardiac output is restored, which suggests an independent cardioprotective effect. A double-blind clinical trial was conducted in patients with a confirmed diagnosis of LCOS randomized into two treatment groups (levosimendan vs. dobutamine). Monitoring of hemodynamic (cardiac index, systolic volume index, heart rate, mean arterial pressure, central venous pressure, central venous saturation); biochemical (e.g. creatinine, S100B protein, NT-proBNP, troponin I); and renal parameters was performed using acute kidney injury scale (AKI scale) and renal and brain ultrasound measurements [vascular resistance index (VRI)] at diagnosis and during the first 48 h. Significant differences were observed between groups in terms of cardiac index, systolic volume index, NT-proBNP, and kidney injury stage at diagnosis. In the levosimendan group, there were significant variations in AKI stage after 24 and 48 h. No significant differences were observed in the other parameters studied. Levosimendan showed a beneficial effect on renal function in LCOS patients after cardiac surgery that was independent from cardiac output and vascular tone. This effect is probably achieved by pharmacological postconditioning. EUDRA CT, identifier 2014-001461-27. https://www.clinicaltrialsregister.eu/ctr-search/search?query=2014-001461-27. eng Cardiac surgery Dobutamine Kidney Levosimendan Low cardiac output Renal and Neurologic Benefit of Levosimendan vs Dobutamine in Patients With Low Cardiac Output Syndrome After Cardiac Surgery: Clinical Trial FIM-BGC-2014-01. research article