2026-04-29T20:47:11Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/180902024-11-28T15:00:08Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud
author
García-Argüello, Segundo Francisco
author
Lopez-Lorenzo, Beatriz
author
Cornelissen, Bart
author
Smith, Graham
authoraffiliation
[García-Argüello,SF] Centro de Investigaciones Médico-Sanitarias, Fundación General Universidad de Málaga, Málaga, Spain. [García-Argüello,SF] Grupo de Arteriosclerosis, Prevención Cardiovascular y Metabolismo, Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain. [Lopez-Lorenzo,B] Biomedicina, Investigación Traslacional y Nuevas Tecnologías en Salud, Universidad de Málaga, Málaga, Spain. [Lopez-Lorenzo,B] BIONAND-Centro Andaluz de Nanomedicina y Biotecnología (Junta de Andalucía—Universidad de Málaga), Málaga, Spain. [Cornelissen,B; Smith,G] Department of Oncology, CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, Old Road Campus Research Building, Oxford, UK.
2024-02-12T19:46:54Z
2024-02-12T19:46:54Z
2020-08-06
10.3390/cancers12082191
2072-6694
Cancers
http://hdl.handle.net/10668/4148
32781531
http://hdl.handle.net/20.500.12105/18090
Insufficient apoptosis is a recognised hallmark of cancer. A strategy to quantitatively measure apoptosis in vivo would be of immense value in both drug discovery and routine patient management. The first irreversible step in the apoptosis cascade is activation of the "executioner" caspase-3 enzyme to commence cleavage of key structural proteins. One strategy to measure caspase-3 activity is Positron Emission Tomography using isatin-5-sulfonamide radiotracers. One such radiotracer is [18F]ICMT-11, which has progressed to clinical application. This review summarises the design and development process for [18F]ICMT-11, suggesting potential avenues for further innovation.
eng
Positron emission tomography
Apoptosis
Caspase-3
[18F]ICMT-11
Pyrimidoindolone
Michael acceptor
Neoplasms
Isatin
Tomografía de emisión de positrones
Caspasa-3
Neoplasias
Isatina
Development of [18F]ICMT-11 for Imaging Caspase-3/7 Activity during Therapy-Induced Apoptosis
review article