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oai:repisalud.isciii.es:20.500.12105/180802024-11-28T15:04:05Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud author Chica-Parrado, María Rosario author Godoy-Ortiz, Ana author Jiménez, Begoña author Ribelles, Nuria author Barragan, Isabel author Alba, Emilio authoraffiliation [Chica-Parrado,MR; Godoy-Ortiz,A; Jiménez,B; Ribelles,N; Barragan,I; Alba,E] Institute of Biomedical Research in Malaga (IBIMA), Regional and Virgen de la Victoria University Hospitals, Málaga, Spain. [Chica-Parrado,MR; Barragan,I; Alba,E] Cancer Molecular Biology Group, Medical Research Center, University of Málaga (UMA), Málaga, Spain. [Godoy-Ortiz,A; Jiménez,B; Ribelles,N; Barragan,I; Alba,E] Medical Oncology Service Intercentros, Regional and Virgen de la Victoria University Hospitals, IBIMA, Málaga, Spain. [Barragan,I] Group of Pharmacoepigenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. 2024-02-12T19:46:45Z 2024-02-12T19:46:45Z 2020-07-22 10.3390/cancers12082012 2072-6694 Cancers http://hdl.handle.net/10668/3761 32708049 http://hdl.handle.net/20.500.12105/18080 Neoadjuvant Chemotherapy (NAC) in Breast Cancer (BC) has proved useful for the reduction in tumor burden prior to surgery, allowing for a more extensive breast preservation and the eradication of subjacent micrometastases. However, the impact on prognosis is highly dependent on the establishment of Pathological Complete Response (pCR), in particular for Triple Negative (TN) and Hormonal Receptor negative/Human Epidermal growth factor Receptor 2 positive (HR-/HER2+) subtypes. Several pCR predictors, such as PAM50, Integrative Cluster (IntClust), mutations in PI3KCA, or the Trastuzumab Risk model (TRAR), are useful molecular tools for estimating response to treatment and are prognostic. Major evolution events during BC NAC that feature the Residual Disease (RD) are the loss of HR and HER2, which are prognostic of bad outcome, and stemness and immune depletion-related gene expression aberrations. This dynamic nature of the determinants of response to BC NAC, together with the extensive heterogeneity of BC, raises the need to discern the individual and subtype-specific determinants of resistance. Moreover, refining the current approaches for a comprehensive monitoring of tumor evolution during treatment, RD, and eventual recurrences is essential for identifying new actionable alterations and the integral best management of the disease. eng Breast cancer Neoadjuvant chemotherapy Pathological complete response Predictive markers Residual disease Neoplasias de la mama Terapia neoadyuvante Trastuzumab Resistance to Neoadjuvant Treatment in Breast Cancer: Clinicopathological and Molecular Predictors review article