2026-07-21T14:05:55Zhttps://repisalud.isciii.es/rest/oai/request
oai:repisalud.isciii.es:20.500.12105/180742024-09-21T23:44:10Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud author Navarro, Juan A author Decara, Juan author Medina-Vera, Dina author Tovar, Rubén author Suarez, Juan|Pavón, Francisco-Javier author Serrano, Antonia author Vida, Margarita author Gutierrez-Adan, Alfonso author Sanjuan, Carlos author Baixeras, Elena author Fonseca, Fernando Rodríguez de 2024-02-12T19:46:39Z 2024-02-12T19:46:39Z 2020-07-08 10.3390/nu12072030 2072-6643 Nutrients http://hdl.handle.net/10668/15920 32650579 http://hdl.handle.net/20.500.12105/18074 To characterize the metabolic actions of D-Pinitol, a dietary inositol, in male Wistar rats, we analyzed its oral pharmacokinetics and its effects on (a) the secretion of hormones regulating metabolism (insulin, glucagon, IGF-1, ghrelin, leptin and adiponectin), (b) insulin signaling in the liver and (c) the expression of glycolytic and neoglucogenesis enzymes. Oral D-Pinitol administration (100 or 500 mg/Kg) resulted in its rapid absorption and distribution to plasma and liver compartments. Its administration reduced insulinemia and HOMA-IR, while maintaining glycaemia thanks to increased glucagon activity. In the liver, D-Pinitol reduced the key glycolytic enzyme pyruvate kinase and decreased the phosphorylation of the enzymes AKT and GSK-3. These observations were associated with an increase in ghrelin concentrations, a known inhibitor of insulin secretion. The profile of D-Pinitol suggests its potential use as a pancreatic protector decreasing insulin secretion through ghrelin upregulation, while sustaining glycaemia through the liver-based mechanisms of glycolysis control. eng AKT D-Pinitol Ghrelin Insulin Insulin resistance Liver Phosphorylation D-Pinitol from Ceratonia siliqua Is an Orally Active Natural Inositol That Reduces Pancreas Insulin Secretion and Increases Circulating Ghrelin Levels in Wistar Rats. research article