2026-05-22T00:27:36Zhttps://repisalud.isciii.es/rest/oai/request
oai:repisalud.isciii.es:20.500.12105/180662024-11-28T14:46:13Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud author Rivera, Patricia author Tovar, Rubén author Ramírez-López, María Teresa author Navarro, Juan Antonio author Vargas, Antonio author Suárez, Juan author Rodríguez de Fonseca, Fernando authoraffiliation [Rivera,P; Tovar,R; Navarro,JA; Vargas,A; Suárez,J; Rodríguez de Fonseca,F] Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Regional Universitario de Málaga, Universidad de Málaga, Málaga, Spain. [Ramírez-López,MT] Hospital Universitario de Getafe, Servicio de Ginecología y Obstetricia, Getafe, Spain. [Ramírez-López,MT] Departamento de Enfermería, Facultad de Enfermería, Fisioterapia y Podología, Universidad Complutense de Madrid, Madrid, Spain. 2024-02-12T19:46:32Z 2024-02-12T19:46:32Z 2020-06-19 10.3390/nu12061829 2072-6643 Nutrients http://hdl.handle.net/10668/4258 32575416 http://hdl.handle.net/20.500.12105/18066 Both maternal and early life malnutrition can cause long-term behavioral changes in the offspring, which depends on the caloric availability and the timing of the exposure. Here we investigated in a rat model whether a high-caloric palatable diet given to the mother and/or to the offspring during the perinatal and/or postnatal period might dysregulate emotional behavior and prefrontal cortex function in the offspring at adult age. To this end, we examined both anxiety responses and the mRNA/protein expression of glutamatergic, GABAergic and endocannabinoid signaling pathways in the prefrontal cortex of adult offspring. Male animals born from mothers fed the palatable diet, and who continued with this diet after weaning, exhibited anxiety associated with an overexpression of the mRNA of Grin1, Gria1 and Grm5 glutamate receptors in the prefrontal cortex. In addition, these animals had a reduced expression of the endocannabinoid system, the main inhibitory retrograde input to glutamate synapses, reflected in a decrease of the Cnr1 receptor and the Nape-pld enzyme. In conclusion, a hypercaloric maternal diet induces sex-dependent anxiety, associated with alterations in both glutamatergic and cannabinoid signaling in the prefrontal cortex, which are accentuated with the continuation of the palatable diet during the life of the offspring. eng Perinatal programming Prefrontal cortex Endocannabinoid system Corteza prefrontal Endocannabinoides Embarazo Ansiedad Dieta alta en grasa Modelos animales Sex-Specific Anxiety and Prefrontal Cortex Glutamatergic Dysregulation Are Long-Term Consequences of Pre-and Postnatal Exposure to Hypercaloric Diet in a Rat Model research article