2026-06-14T03:44:53Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/180612024-11-28T15:31:10Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16938col_20.500.12105_16927

00925njm 22002777a 4500 dc Paris, Juan L. author Vallet-Regí, María author 2020-06-08 Mesoporous silica nanoparticles have attracted much attention in recent years as drug and gene delivery systems for biomedical applications. Among their most beneficial features for biomedicine, we can highlight their biocompatibility and their outstanding textural properties, which provide a great loading capacity for many types of cargos. In the context of cancer nanomedicine, combination therapy and gene transfection/silencing have recently been highlighted as two of its most promising fields. In this review, we aim to provide an overview of the different small molecule drug-nucleic acid co-delivery combinations that have been developed using mesoporous silica nanoparticles as carriers. By carefully selecting the chemotherapeutic drug and nucleic acid cargos to be co-delivered by mesoporous silica nanoparticles, different therapeutic goals can be achieved by overcoming resistance mechanisms, combining different cytotoxic mechanisms, or providing an additional antiangiogenic effect. The examples here presented highlight the great promise of this type of strategies for the development of future therapeutics. 10.3390/pharmaceutics12060526 1999-4923 Pharmaceutics http://hdl.handle.net/10668/3585 32521800 http://hdl.handle.net/20.500.12105/18061 Mesoporous silica nanoparticles Co-delivery Drug delivery Nucleic acids Gene transfection Nanomedicine Dióxido de silicio Nanopartículas Sistemas de liberación de medicamentos Ácidos nucleicos Transfección Nanomedicina Mesoporous Silica Nanoparticles for Co-Delivery of Drugs and Nucleic Acids in Oncology: A Review