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oai:repisalud.isciii.es:20.500.12105/180602024-11-28T14:44:22Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927col_20.500.12105_16981
Repisalud author Sánchez-Alcoholado, Lidia author Ramos-Molina, Bruno author Otero, Ana author Laborda-Illanes, Aurora author Ordóñez, Rafael author Medina, José Antonio author Gómez-Millán, Jaime author Queipo-Ortuño, María Isabel authoraffiliation [Sánchez-Alcoholado,L; Laborda-Illanes,A; Queipo-Ortuño,MI] Unidad de Gestión Clínica Intercentros de Oncología Médica, Hospitales Universitarios Regional y Virgen de la Victoria. Instituto de Investigación Biomédica de Málaga (IBIMA)-CIMES-UMA, Málaga, Spain. [Ramos-Molina,B] Departamento de Cirugía Digestiva, Endocrina y Transplante de Órganos Abdominales, Instituto Murciano de Investigación Biosanitária (IMIB-Arrixaca), Murcia, Spain. [Otero,A; Ordóñez,R; Medina,JA; Gómez-Millán,J] Unidad de Gestión Clínica de Oncología Radioterápica, Hospital Universitario Virgen de la Victoria. Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain. 2024-02-12T19:46:26Z 2024-02-12T19:46:26Z 2020-05-29 10.3390/cancers12061406 2072-6694 Cancers http://hdl.handle.net/10668/3648 32486066 http://hdl.handle.net/20.500.12105/18060 Colorectal cancer (CRC) is the third most common cancer worldwide and the leading cause of cancer-related deaths. Recently, several studies have demonstrated that gut microbiota can alter CRC susceptibility and progression by modulating mechanisms such as inflammation and DNA damage, and by producing metabolites involved in tumor progression or suppression. Dysbiosis of gut microbiota has been observed in patients with CRC, with a decrease in commensal bacterial species (butyrate-producing bacteria) and an enrichment of detrimental bacterial populations (pro-inflammatory opportunistic pathogens). CRC is characterized by altered production of bacterial metabolites directly involved in cancer metabolism including short-chain fatty acids and polyamines. Emerging evidence suggests that diet has an important impact on the risk of CRC development. The intake of high-fiber diets and the supplementation of diet with polyunsaturated fatty acids, polyphenols and probiotics, which are known to regulate gut microbiota, could be not only a potential mechanism for the reduction of CRC risk in a primary prevention setting, but may also be important to enhance the response to cancer therapy when used as adjuvant to conventional treatment for CRC. Therefore, a personalized modulation of the pattern of gut microbiome by diet may be a promising approach to prevent the development and progression of CRC and to improve the efficacy of antitumoral therapy. eng Colorectal cancer Gut microbiota Dysbiosis Inflammation Short-chain fatty acids Polyamines Dietary fiber Polyunsaturated fatty acids Polyphenols Probiotics Neoplasias colorrectales Microbioma gastrointestinal Disbiosis Inflamación Ácidos grasos volátiles Poliaminas Fibras de la dieta Ácidos grasos insaturados Polifenoles Probióticos The Role of the Gut Microbiome in Colorectal Cancer Development and Therapy Response review article