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00925njm 22002777a 4500 dc Marcos-Delgado, Alba author Fernández-Villa, Tania author Martínez-González, Miguel Ángel author Salas-Salvadó, Jordi author Corella, Dolores author Castañer, Olga author Martínez, J. Alfredo author Alonso-Gómez, Ángel M. author Wärnberg, Julia author Vioque, Jesús author Romaguera, Dora author López-Miranda, José author Estruch, Ramon author Tinahones, Francisco J. author Lapetra, José author Serra-Majem, J. LLuís author García-Molina, Laura author Tur, Josep A. author de Paz, José Antonio author Pintó, Xavier author Delgado-Rodríguez, Miguel author Matía-Martín, Pilar author Vidal, Josep author Vázquez, Clotilde author Daimiel, Lidia author Ros, Emilio author Babio, Nancy author Gimenez-Alba, Ignacio M. author Toledo, Estefanía author Zomeño, María Dolores author Zulet, M. A. author Vaquero-Luna, Jessica author Pérez-López, Jessica author Pastor-Morel, Ana author Galmes-Panades, Aina M. author García-Rios, Antonio author Casas, Rosa author Bernal-López, María Rosa author Santos-Lozano, José Manuel author Becerra-Tomás, Nerea author Ortega-Azorin, Carolina author Vázquez-Ruiz, Zenaida author Pérez-Vega, Karla Alejandra author Abete, Itziar author Sorto-Sánchez, Carolina author Palau-Galindo, Antoni author Galilea-Zabalza, Iñigo author Muñoz-Martínez, Júlia author Martín, Vicente author 2020-05-25 The main objective of this study was to examine the relationship between the level of physical activity (PA) and the degree of obesity with health-related quality of life (HRQoL) in individuals with metabolic syndrome (MetS) who participated in the Predimed-Plus study. A total of 6875 subjects between 55 and 75 years of age with MetS were selected and randomized in 23 Spanish centers. Subjects were classified according to categories of body mass index (BMI). PA was measured with the validated Registre Gironí del Cor (REGICOR) questionnaire and subjects were classified according to their PA level (light, moderate, vigorous) and the HRQoL was measured with the validated short-form 36 (SF-36) questionnaire. By using the ANOVA model, we found a positive and statistically significant association between the level of PA and the HRQoL (aggregated physical and mental dimensions p < 0.001), but a negative association with higher BMI in aggregated physical dimensions p < 0.001. Furthermore, women obtained lower scores compared with men, more five points in all fields of SF-36. Therefore, it is essential to promote PA and body weight control from primary care consultations to improve HRQoL, paying special attention to the differences that sex incurs. 10.3390/ijerph17103728 1660-4601 1661-7827 International Journal of Environmental Research and Public Health http://hdl.handle.net/10668/4368 http://hdl.handle.net/20.500.13003/10764 32466190 L2004441273 2-s2.0-85085635429 http://hdl.handle.net/20.500.12105/18057 539300900385 Health-related quality of life Physical activity Obesity Body mass index Metabolic syndrome Calidad de vida Ejercicio físico Obesidad Índice de masa corporal Síndrome metabólico The Effect of Physical Activity and High Body Mass Index on Health-Related Quality of Life in Individuals with Metabolic Syndrome