2026-04-29T12:23:09Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/180432024-02-12T19:46:07Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927col_20.500.12105_16960col_20.500.12105_16963
Repisalud
author
Cabrejos, Sheila
author
Moreira, Ana
author
Ramirez, Andreina
author
Quirce, Santiago
author
Soto Campos, Gregorio
author
Dávila, Ignacio
author
Campo, Paloma
2024-02-12T19:46:07Z
2024-02-12T19:46:07Z
2020-05-06
10.2147/JAA.S246902
1178-6965
Journal of asthma and allergy
http://hdl.handle.net/10668/15615
32440161
http://hdl.handle.net/20.500.12105/18043
A Spanish real-world study in patients with severe persistent asthma who achieved asthma control after a one-year treatment with omalizumab highlighted the phenotypic heterogeneity of these patients (FENOMA study). In this subanalysis, we describe the clinical improvement in patients with severe allergic asthma in this study (positive skin test and IgE level 30-1500 IU/mL); n=240. FENOMA was an observational, multicentre, retrospective study in 345 patients achieving asthma control according to Spanish guidelines (GEMA). Baseline demographic and asthma-related characteristics were collected. Outcomes analyzed were those included in asthma control definition plus changes in background treatments and in blood eosinophil count (%) and exhaled nitric oxide fraction [FeNO]. At baseline, patients were aged 45.4±15.0 years; 67% were women. Median (Q1;Q3) IgE levels were 302.5 (154.0; 553.5) IU/mL. After one-year treatment with omalizumab: 43.3% of patients had daytime symptoms vs 97.7% before treatment and 49.6% stopped taking oral corticosteroids. FEV1 increased a median of 12.0 (4.0; 23.0)%; P This study highlights the asthma control achieved by patients with severe allergic asthma treated with omalizumab, with relevant benefits on the burden of the disease both on patients and the healthcare system.
eng
IgE
Allergy
Asthma
Exacerbations
Omalizumab
FENOMA Study: Achieving Full Control in Patients with Severe Allergic Asthma.
research article