2026-08-12T20:37:12Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/180382024-11-28T15:21:52Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927col_20.500.12105_16982
Repisalud
author
Clemente-Postigo, Mercedes
author
Tinahones, Alberto
author
El Bekay, Rajaa
author
Malagón, María M.
author
Tinahones, Francisco J.
authoraffiliation
[Clemente-Postigo,M; Malagón,MM] Department of Cell Biology, Physiology and Immunology, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC)-Reina Sofia University Hospital, University of Cordoba, Edificio IMIBIC, Córdoba, Spain. [Tinahones,A; Tinahones,FJ] Unidad de Gestión Clínica de Endocrinología y Nutrición (Hospital Universitario Virgen de la Victoria), Instituto de Investigación Biomédica de Málaga (IBIMA), Universidad de Málaga, Málaga, Spain. [El Bekay,R] Unidad de Gestión Clínica de Endocrinología y Nutrición (Hospital Universitario Regional de Málaga), Instituto de Investigación Biomédica de Málaga (IBIMA), Universidad de Málaga, Málaga, Spain. [El Bekay,R; Malagón,MM; Tinahones,FJ] Centro de Investigación Biomédica en Red (CIBER) Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
2024-02-12T19:46:03Z
2024-02-12T19:46:03Z
2020-04-30
10.3390/metabo10050179
2218-1989
Metabolites
http://hdl.handle.net/10668/3533
32365782
http://hdl.handle.net/20.500.12105/18038
White adipose tissue (WAT) is a highly adaptive endocrine organ that continuously remodels in response to nutritional cues. WAT expands to store excess energy by increasing adipocyte number and/or size. Failure in WAT expansion has serious consequences on metabolic health resulting in altered lipid, glucose, and inflammatory profiles. Besides an impaired adipogenesis, fibrosis and low-grade inflammation also characterize dysfunctional WAT. Nevertheless, the precise mechanisms leading to impaired WAT expansibility are yet unresolved. Autophagy is a conserved and essential process for cellular homeostasis, which constitutively allows the recycling of damaged or long-lived proteins and organelles, but is also highly induced under stress conditions to provide nutrients and remove pathogens. By modulating protein and organelle content, autophagy is also essential for cell remodeling, maintenance, and survival. In this line, autophagy has been involved in many processes affected during WAT maladaptation, including adipogenesis, adipocyte, and macrophage function, inflammatory response, and fibrosis. WAT autophagy dysregulation is related to obesity and diabetes. However, it remains unclear whether WAT autophagy alteration in obese and diabetic patients are the cause or the consequence of WAT malfunction. In this review, current data regarding these issues are discussed, focusing on evidence from human studies.
eng
Adipose tissue
Adipocyte
Autophagy
Obesity
Diabetes
Metabolism
Tejido adiposo
Adipocitos
Autofagia
Obesidad
Diabetes Mellitus
Metabolismo
The Role of Autophagy in White Adipose Tissue Function: Implications for Metabolic Health
review article