2026-05-22T00:40:08Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/180262024-11-28T14:44:41Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927

00925njm 22002777a 4500 dc Ocaña, M. Carmen author Martínez-Poveda, Beatriz author Marí-Beffa, Manuel author Quesada, Ana R. author Medina, Miguel Ángel author 2020-04-09 The synthetic compound fasentin has been described as a modulator of GLUT-1 and GLUT-4 transporters, thus inhibiting glucose uptake in some cancer cells. Endothelial glucose metabolism has been recently connected to angiogenesis and it is now an emerging topic in scientific research. Indeed, certain compounds with a known effect on glucose metabolism have also been shown to inhibit angiogenesis. In this work we tested the capability of fasentin to modulate angiogenesis in vitro and in vivo. We show that fasentin inhibited tube formation in endothelial cells by a mechanism that involves a negative effect on endothelial cell proliferation and invasion, without affecting other steps related to the angiogenic process. However, fasentin barely decreased glucose uptake in human dermal microvascular endothelial cells and the GLUT-1 inhibitor STF-31 failed to inhibit tube formation in these cells. Therefore, this modulatory capacity on endothelial cells function exerted by fasentin is most likely independent of a modulation of glucose metabolism. Taken together, our results show a novel biological activity of fasentin, which could be evaluated for its utility in cancer and other angiogenesis-dependent diseases. 10.1038/s41598-020-63232-z 2045-2322 Scientific Reports http://hdl.handle.net/10668/4149 32273578 http://hdl.handle.net/20.500.12105/18026 Anilides Endothelial cells Glucose Cell proliferation Anilidas Células endoteliales Glucosa Proliferación celular Fasentin diminishes endothelial cell proliferation, differentiation and invasion in a glucose metabolism-independent manner