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00925njm 22002777a 4500 dc Gallardo-Alfaro, Laura author Bibiloni, Maria Del Mar author Mascaró, Catalina M author Montemayor, Sofía author Ruiz-Canela, Miguel author Salas-Salvadó, Jordi author Corella, Dolores author Fitó, Montserrat author Romaguera, Dora author Vioque, Jesús author Alonso-Gómez, Ángel M author Wärnberg, Julia author Martínez, J Alfredo author Serra-Majem, Lluís author Estruch, Ramon author Fernández-García, José Carlos author Lapetra, José author Pintó, Xavier author García Ríos, Antonio author Bueno-Cavanillas, Aurora author Gaforio, José J author Matía-Martín, Pilar author Daimiel, Lidia author Micó-Pérez, Rafael M author Vidal, Josep author Vázquez, Clotilde author Ros, Emilio author Fernandez-Lázaro, Cesar Ignacio author Becerra-Tomás, Nerea author Gimenez-Alba, Ignacio Manuel author Zomeño, María Dolors author Konieczna, Jadwiga author Compañ-Gabucio, Laura author Tojal-Sierra, Lucas author Pérez-López, Jéssica author Zulet, M Ángeles author Casañas-Quintana, Tamara author Castro-Barquero, Sara author Gómez-Pérez, Ana María author Santos-Lozano, José Manuel author Galera, Ana author Basterra-Gortari, F Javier author Basora, Josep author Saiz, Carmen author Pérez-Vega, Karla Alejandra author Galmés-Panadés, Aina M author Tercero-Maciá, Cristina author Sorto-Sánchez, Carolina author Sayón-Orea, Carmen author García-Gavilán, Jesús author Muñoz-Martínez, Júlia author Tur, Josep A author 2020-04-07 Healthy lifestyle factors, such as physical activity (PA) and Mediterranean diet (MD), decrease the likelihood of developing metabolic syndrome (MetS). The aim of this study was to report main lifestyle components and related factors according to the MetS severity. Cross-sectional analysis was done of baseline lifestyle factors from 5739 participants with overweight/obesity and MetS features (aged 55-75 years) included in the PREDIMED-PLUS primary cardiovascular prevention randomized trial. Participants were categorized in tertiles according to a validated MetS severity score (MetSSS). Anthropometrics, visceral adiposity index, dietary nutrient intake, biochemical marker levels, as well as a Dietary Inflammatory Index and depression symptoms (Beck Depression Inventory-II) were measured. Diet quality was assessed using a 17-item energy-restricted MD questionnaire. Duration and intensity of PA was self-reported using the Minnesota-REGICOR Short Physical Activity Questionnaire. Sedentary behaviours were measured using the Spanish version of the Nurses' Health Study questionnaire. The 30 s chair stand test was also assessed. Participants with highest MetSSS showed higher values of cardiovascular risk factors (except for total cholesterol and LDL cholesterol), depression risk, sedentary and TV viewing time, and lower moderate and vigorous leisure-time physical activity (LTPA). Highest MetSSS participants tended to a pro-inflammatory dietary pattern and tended to lower MD adherence. In addition, they showed lower carbohydrate and nut intake and higher intake of protein, saturated and trans fatty acids, cholesterol, iodine, sodium, red and processed meat products, other oils different from olive oil and spirit alcoholic drinks. The highest MetS severity score was associated with lower moderate and vigorous LTPA and higher sedentary time and depression risk, as they tended to a pro-inflammatory dietary pattern and lower MD adherence. 10.3390/nu12041013 2072-6643 Nutrients http://hdl.handle.net/10668/15350 http://hdl.handle.net/20.500.13003/11121 32272653 L2004152849 2-s2.0-85083256628 http://hdl.handle.net/20.500.12105/18024 531831300133 Mediterranean diet depression risk metabolic syndrome severity physical activity sedentary behaviour Leisure-Time Physical Activity, Sedentary Behaviour and Diet Quality are Associated with Metabolic Syndrome Severity: The PREDIMED-Plus Study