2026-04-28T21:35:15Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/180222024-11-28T15:27:23Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud
author
Molina, Noemi
author
González, Ana
author
Monopoli, Donato
author
Mentado, Belinda
author
Becerra, José
author
Santos-Ruiz, Leonor
author
Vida, Yolanda
author
Perez-Inestrosa, Ezequiel
authoraffiliation
[Molina,N; Vida,Y; Perez-Inestrosa,E] Universidad de Málaga - IBIMA, Dpto. Química Orgánica, Málaga, Spain. [Molina,N; González,A; Becerra,J; Santos-Ruiz,L; Vida,Y; Perez-Inestrosa,E] Centro Andaluz de Nanomedicina y Biotecnología-BIONAND. Parque Tecnológico de Andalucía, Campanillas, Málaga, Spain. [González,A; Becerra,J; Santos-Ruiz,L] Universidad de Málaga - IBIMA, Dpto. Biología Celular, Genética y Fisiología, Facultad de Ciencias, Málaga, Spain. [Monopoli,D; Mentado,B] Departamento de Ingeniería Biomédica. Instituto Tecnológico de Canarias, Agüimes, Las Palmas, Spain. [Monopoli,D; Mentado,B] Osteobionix s.l. Las Palmas de Gran Canaria, Spain. [Becerra,J; Santos-Ruiz,L] Centro de Investigación Biomédica en Red - Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, Spain.
2024-02-12T19:45:45Z
2024-02-12T19:45:45Z
2020-04-01
http://hdl.handle.net/10668/3530
http://hdl.handle.net/20.500.12105/18022
32244665
10.3390/polym12040770
2073-4360
Polymers
Osseointegration of metal prosthetic implants is a yet unresolved clinical need that depends on the interplay between the implant surface and bone cells. The lack of a relationship between bone cells and metal has traditionally been solved by coating the former with "organic" ceramics, such as hydroxyapatite. A novel approach is hereby presented, immobilizing covalently dendrimeric structures onto titanium implants. Amide-based amino terminal dendrons were synthetized and coupled to titanium surfaces in a versatile and controlled way. The dendritic moieties provide an excellent scaffold for the covalent immobilization of bioactive molecules, such as extracellular matrix (ECM) protein components or antibiotics. Herein, tripeptide arginine-glycine-aspartic acid (RGD) motifs were used to decorate the dendritic scaffolds and their influence on cell adhesion and proliferation processes was evaluated.
eng
Dendritic structures
Titanium implants
Tripeptide arginine-glycine-aspartic acid (RGD) recognition pattern
Materials testing
Cell adhesion
Titanio
Oseointegración
Prótesis e implantes
Ensayo de materiales
Adhesión celular
Dendrímeros
Dendritic Scaffold onto Titanium Implants. A Versatile Strategy Increasing Biocompatibility
research article