2026-04-28T21:35:14Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/180222024-11-28T15:27:23Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927

00925njm 22002777a 4500 dc Molina, Noemi author González, Ana author Monopoli, Donato author Mentado, Belinda author Becerra, José author Santos-Ruiz, Leonor author Vida, Yolanda author Perez-Inestrosa, Ezequiel author 2020-04-01 Osseointegration of metal prosthetic implants is a yet unresolved clinical need that depends on the interplay between the implant surface and bone cells. The lack of a relationship between bone cells and metal has traditionally been solved by coating the former with "organic" ceramics, such as hydroxyapatite. A novel approach is hereby presented, immobilizing covalently dendrimeric structures onto titanium implants. Amide-based amino terminal dendrons were synthetized and coupled to titanium surfaces in a versatile and controlled way. The dendritic moieties provide an excellent scaffold for the covalent immobilization of bioactive molecules, such as extracellular matrix (ECM) protein components or antibiotics. Herein, tripeptide arginine-glycine-aspartic acid (RGD) motifs were used to decorate the dendritic scaffolds and their influence on cell adhesion and proliferation processes was evaluated. http://hdl.handle.net/10668/3530 http://hdl.handle.net/20.500.12105/18022 32244665 10.3390/polym12040770 2073-4360 Polymers Dendritic structures Titanium implants Tripeptide arginine-glycine-aspartic acid (RGD) recognition pattern Materials testing Cell adhesion Titanio Oseointegración Prótesis e implantes Ensayo de materiales Adhesión celular Dendrímeros Dendritic Scaffold onto Titanium Implants. A Versatile Strategy Increasing Biocompatibility