2026-04-29T04:09:30Zhttps://repisalud.isciii.es/rest/oai/request
oai:repisalud.isciii.es:20.500.12105/180162024-11-28T15:43:31Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud author Delgado-Martín, Belén author Medina, Miguel Ángel authoraffiliation [Delgado-Martín,B; Medina,MA] Department of Molecular Biology and Biochemistry Faculty of Sciences, University of Málaga Málaga, Spain. [Medina,MA] IBIMA (Biomedical Research Institute of Málaga) Málaga, Spain. [Medina,MA] CIBER de Enfermedades Raras (CIBERER) Málaga, Spain. 2024-02-12T19:45:40Z 2024-02-12T19:45:40Z 2020-03-12 http://hdl.handle.net/10668/3649 http://hdl.handle.net/20.500.12105/18016 32382477 10.1002/advs.201902971 2198-3844 Advanced Science Gliomas are the most common primary brain tumors in adults. They arise in the glial tissue and primarily occur in the brain. Low-grade tumors of World Health Organization (WHO) grade II tend to progress to high-grade gliomas of WHO grade III and, eventually, glioblastoma of WHO grade IV, which is the most common and deadly glioma, with a median survival of 12-15 months after final diagnosis. Knowledge of the molecular biology and genetics of glioblastoma has increased significantly in the past few years, giving rise to classification methods that can help in management and stratification of glioblastoma patients. However, glioblastoma remains an incurable disease. Glioblastoma cells have acquired genetic and metabolic adaptations in order to sustain tumor growth and progression, including changes in energetic metabolism, invasive capacity, migration, and angiogenesis, that make it very difficult to find suitable therapeutic targets and to develop effective drugs. The current standard of care for glioblastoma patients is surgery followed by radiotherapy plus concomitant and adjuvant chemotherapy with temozolomide. Although progress in glioblastoma therapies in recent years has been more limited than in other tumors, numerous drugs and targets are being proposed and many clinical trials are underway to develop effective subtype-specific treatments. eng Cancer therapy Diagnostics Glioblastoma Patient stratification Diagnóstico Neoplasias Preparaciones farmacéuticas Terapéutica Encéfalo Advances in the Knowledge of the Molecular Biology of Glioblastoma and Its Impact in Patient Diagnosis, Stratification, and Treatment review article