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oai:repisalud.isciii.es:20.500.12105/180132024-11-28T15:02:26Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927

00925njm 22002777a 4500 dc Pozo-Torres, Esther author Caro, Carlos author Avasthi, Ashish author Páez-Muñoz, Jose María author García-Martín, María Luisa author Fernández, Inmaculada author Pernia Leal, Manuel author 2020-03-05 Clickable magnetic nanoparticles have attracted great attention as potential nanoplatforms for biomedical applications because of the high functionalization efficiency of their surfaces with biomolecules, which facilitates their bio-compatibilization. However, the design and synthesis of clickable NPs is still challenging because of the complexity of the chemistry on the magnetic NP surface, thus robust methods that improve the ligand synthesis and the transfer of magnetic NPs in physiological media being in high-demand. In this work, we developed a versatile and enhanced synthetic route to fabricate potentially clickable IONPs of interest in nanomedicine. Catechol anchor ligands with different stereo-electronic features were synthetized from a hetero bi-functional PEG spacer backbone. The resulting catechol ligands transferred in good yields and high stability to magnetic NPs by an improved energetic ligand exchange method that combines sonication and high temperature. The azido functionalized IONPs exhibited excellent characteristics as T2 MRI contrast agents with low cytotoxicity, making these clickable magnetic NPs promising precursors for nanomedicines. 10.1039/c9sm02512j 1744-6848 1744-683X Soft Matter http://hdl.handle.net/10668/3376 32163076 http://hdl.handle.net/20.500.12105/18013 Catecoles Ligandos Nanopartículas del metal Nanomedicina Compuestos férricos Química Clic Clickable iron oxide NPs based on catechol derived ligands: synthesis and characterization