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oai:repisalud.isciii.es:20.500.12105/180082024-11-28T15:44:21Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927

00925njm 22002777a 4500 dc Boughanem, Hatim author Bandera-Merchán, Borja author Hernández-Alonso, Pablo author Moreno-Morales, Noelia author Tinahones, Francisco José author Lozano, José author Morcillo, Sonsoles author Macias-Gonzalez, Manuel author 2020-02-27 Background: The interaction between obesity and genetic traits on high density lipoprotein (HDL) levels has been extensively studied. The variance of serum HDL has a strong genetic heritability, although the studied variant only explains a small part of this variation. The goal of this study was to investigate the associations between the apolipoprotein type 2 (APOA2) rs3813627 single nucleotide polymorphism (SNP) and anthropometric and biochemical variables, though body mass index (BMI). Methods: This study included 153 subjects (91 overweight/obese (BMI³25 kg/m2) and 62 non-obese individuals (BMI < 25 kg/m2)). The APOA2 rs3813627 SNP was selected and genotyped. Genotype analysis was performed to analyze the associations between APOA2 SNPs and anthropometric and biochemical variables through BMI. Results: The APOA2 rs3813627 TT genotype was associated with low HDL levels in comparison with the APOA2 rs3813627 GG and GT genotype in overweight/obese individuals, but not in the non-obese subjects (p < 0.05). The same trend was observed in the apolipoprotein type 1 (APOA1) protein levels (p < 0.05). Correlation analysis revealed a negative correlation between HDL and APOA1 levels and APOA2 rs3813627 SNP under recessive model (p < 0.05). The odds ratio for low HDL levels was 3.76 and 3.94 for low APOA1 levels. The mediation analysis of APOA2 rs3813627 SNP through BMI showed a full mediation on HDL and partial mediation on APOA1 levels (p < 0.05). Bioinformatic analysis showed that rs3813627 lies in the APOA2 promoter and overlaps motifs for several bound transcription factors. Conclusion: On the basis of these data, the APOA2 rs3813627 SNP is associated with low HDL and APOA1 levels susceptibility, and this effect was mediated by an increased BMI. 10.3390/biomedicines8030044 2227-9059 Biomedicines http://hdl.handle.net/10668/4167 32120838 http://hdl.handle.net/20.500.12105/18008 rs3813627 APOA1 APOA2 HDL BMI SNP Body mass index Genotype Single nucleotide polymorphism High density lipoprotein Apolipoprotein type 1 Apolipoprotein type 2 Índice de masa corporal Genotipo Polimorfismo de nucleótido simple Lipoproteínas HDL Association between the APOA2 rs3813627 Single Nucleotide Polymorphism and HDL and APOA1 Levels Through BMI