2026-08-13T07:21:17Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/179832024-09-21T19:02:49Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927col_20.500.12105_16989

00925njm 22002777a 4500 dc Campos-Balea, Begoña author de Castro Carpeño, Javier author Massutí, Bartomeu author Vicente-Baz, David author Pérez Parente, Diego author Ruiz-Gracia, Pedro author Crama, Leonardo author Cobo Dols, Manuel author 2020 Background: Lung adenocarcinoma (ADC) is the main cause of death related to lung cancer. The aim of this study was to identify poor prognostic factors for overall survival (OS) in patients with stage IV lung ADC in real-world clinical practice. Methods: Patients were selected from the Surveillance Epidemiology and End Results (SEER) database. Chi-square bivariate analysis was used for the association of binary qualitative variables. A multivariate Cox regression analysis was performed to determine the impact of these prognostic factors on OS. Results: A total of 46 030 patients were included (51.3% men, mean age 67.03 ± 11.6), of whom 41.3% presented with metastases in bone, 28.9% in brain, 17.1% in liver and 31.8% in lung. Patients with liver metastases presented with two or more metastatic sites more frequently than patients without liver metastases (P < 0.001). Male sex (HR 0.78, 95% CI: 0.76-0.80), age ≥ 65 years (HR 1.37, 95% CI: 1.33-1.40), lack of family support (HR 0.80, 95% CI: 0.78-0.81) and presence of liver (HR 1.45, 95% CI: 1.40-1.50), bone (HR 1.21, 95% CI: 1.18-1.24) or brain metastases (HR 1.18, 95% CI: 1.15-1.21) were identified as poor prognostic factors for OS. Patients with liver metastasis showed the highest hazard ratio value (P < 0.001). Conclusions: The presence of liver metastases was the worst prognostic factor for patients with metastatic lung ADC. This factor should be considered as a stratification factor for future studies evaluating new cancer treatments including immunotherapy. 10.1111/1759-7714.13681 1759-7714 1759-7706 Thoracic Cancer http://hdl.handle.net/10668/3848 32986309 http://hdl.handle.net/20.500.12105/17983 Lung adenocarcinoma Metastasis Non-small cell lung cancer Overall survival Prognostic factor Adenocarcinoma del pulmón Metástasis neoplásica Carcinoma de pulmón de células no pequeñas Pronóstico Prognostic factors for survival in patients with metastatic lung adenocarcinoma: An analysis of the SEER database