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oai:repisalud.isciii.es:20.500.12105/179802024-09-21T19:23:05Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud author Perez, Antonio author Carrasco-Sánchez, Francisco Javier author González, Carlos author Seguí-Ripoll, José Miguel author Trescolí, Carlos author Ena, Javier author Borrell, Mireia author Gomez Huelgas, Ricardo 2024-02-12T19:45:00Z 2024-02-12T19:45:00Z 2020 http://hdl.handle.net/10668/16256 http://hdl.handle.net/20.500.12105/17980 32928792 10.1136/bmjdrc-2020-001518 2052-4897 BMJ open diabetes research & care This study assessed the efficacy and safety of insulin glargine 300 U/mL (Gla-300) during hospitalization and therapy intensification at discharge in insufficiently controlled people with type 2 diabetes. COBALTA (for its acronym in Spanish, COntrol Basal durante la hospitalizacion y al ALTA) was a multicenter, open-label, single-arm, phase IV trial including 112 evaluable inpatients with type 2 diabetes insufficiently controlled (glycosylated hemoglobin (HbA1c) 8%-10%) with basal insulin and/or non-insulin antidiabetic drugs. Patients were treated with a basal-bolus-correction insulin regimen with Gla-300 during the hospitalization and with Gla-300 and/or non-insulin antidiabetics for 6 months after discharge. The primary endpoint was the HbA1c change from baseline to month 6 postdischarge. HbA1c levels decreased from 8.8%±0.6% at baseline to 7.2%±1.1% at month 6 postdischarge (p Inpatient and intensification therapy at discharge with Gla-300 improved significantly glycemic control of patients with type 2 diabetes insufficiently controlled with other basal insulin and/or non-insulin antidiabetic medication, with high treatment satisfaction. Gla-300 could therefore be a treatment choice for hospital and postdischarge diabetes management. eng Blood Glucose Diabetes mellitus Hypoglycemia Insulin glargine Type 2 Efficacy and safety of insulin glargine 300 U/mL (Gla-300) during hospitalization and therapy intensification at discharge in patients with insufficiently controlled type 2 diabetes: results of the phase IV COBALTA trial. research article