2026-05-22T01:43:47Zhttps://repisalud.isciii.es/rest/oai/request
oai:repisalud.isciii.es:20.500.12105/179792024-02-12T19:45:00Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud author Alba-Linero, Carmen author Rodriguez Calvo de Mora, Marina author Lavado Valenzuela, Rocío author Pascual Cascón, María Jesús author Martín Cerezo, Alejandra Rosario author Álvarez Pérez, Martina author Recio, Luis Vicioso author Jerez Aragonés, José Manuel author García Campos, José Manuel 2024-02-12T19:45:00Z 2024-02-12T19:45:00Z 2020 10.4103/ijo.IJO_1865_19 1998-3689 Indian journal of ophthalmology http://hdl.handle.net/10668/15997 32709775 http://hdl.handle.net/20.500.12105/17979 To characterize anatomical and functional changes in the ocular surface after hematopoietic stem cell transplantation. Three groups of patients were included in the study. Group 1: patients who had undergone allogeneic hematopoietic stem cell transplantation (HSCT) (n = 26). Group 2: patients who developed chronic graft versus host disease (GvHD) after HSCT (n = 14). Group 3: healthy subjects (n = 20). A complete ophthalmological examination was undertaken in all subjects, including Schirmer's test, TBUT (break-up-time) test, Oxford scale, OSDI test, corneal tomography, and conjunctival CD8+ lymphocyte detection. In Branch 1 (comparative analysis before and after HSCT in Group 1), statistically significant differences were found in the following variables: best-corrected visual acuity (BCVA) OD (P = 0.08), OSDI test (P = 0.003), TBUT OU (OD P= 0, OS P= 0.0003), Oxford test OU (OD P= 0.01, OS P= 0.0049), and CD8+ lymphocytes OU (OD P= 0.003, OS P= 0.01). In Branch 2 (comparative analysis between Group 2 and 3), the variables with statistically significant differences (P In our study, statistically significant changes were observed in the OSDI test, TBUT test, Oxford Scale, and the detection of CD8+ lymphocytes in patients who underwent HSCT. Differences were more significant in those patients who had developed GvHD after HSCT compared to those without GvHD. eng Allogeneic stem cell transplantation OSDI test Schirmer's test conjunctival CD8+ lymphocyte detection graft-versus-host disease Ocular surface characterization after allogeneic stem cell transplantation: A prospective study in a referral center. research article