2026-05-21T23:11:23Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/179742024-11-29T13:28:21Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud
author
Becker, Annette
author
Thakur, Basant Kumar
author
Weiss, Joshua Mitchell
author
Kim, Han Sang
author
Peinado, Hector
author
Lyden, David
2024-02-12T12:25:41Z
2024-02-12T12:25:41Z
2016-12-12
Cancer Cell . 2016;30(6):836-848.
10.1016/j.ccell.2016.10.009
1878-3686
Cancer cell
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC
27960084
http://hdl.handle.net/20.500.12105/17974
Tumor-secreted extracellular vesicles (EVs) are critical mediators of intercellular communication between tumor cells and stromal cells in local and distant microenvironments. Accordingly, EVs play an essential role in both primary tumor growth and metastatic evolution. EVs orchestrate multiple systemic pathophysiological processes, such as coagulation, vascular leakiness, and reprogramming of stromal recipient cells to support pre-metastatic niche formation and subsequent metastasis. Clinically, EVs may be biomarkers and novel therapeutic targets for cancer progression, particularly for predicting and preventing future metastatic development.
eng
Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis.
journal article
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