2026-05-21T23:20:03Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/179742024-11-29T13:28:21Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597

00925njm 22002777a 4500 dc Becker, Annette author Thakur, Basant Kumar author Weiss, Joshua Mitchell author Kim, Han Sang author Peinado, Hector author Lyden, David author 2016-12-12 Tumor-secreted extracellular vesicles (EVs) are critical mediators of intercellular communication between tumor cells and stromal cells in local and distant microenvironments. Accordingly, EVs play an essential role in both primary tumor growth and metastatic evolution. EVs orchestrate multiple systemic pathophysiological processes, such as coagulation, vascular leakiness, and reprogramming of stromal recipient cells to support pre-metastatic niche formation and subsequent metastasis. Clinically, EVs may be biomarkers and novel therapeutic targets for cancer progression, particularly for predicting and preventing future metastatic development. Cancer Cell . 2016;30(6):836-848. 10.1016/j.ccell.2016.10.009 1878-3686 Cancer cell https://www.ncbi.nlm.nih.gov/pmc/articles/PMC 27960084 http://hdl.handle.net/20.500.12105/17974 Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis.