2026-04-29T06:15:47Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/179532024-09-27T07:59:57Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Echarri, Asier
author
Del Pozo, Miguel A
2024-02-12T08:11:50Z
2024-02-12T08:11:50Z
2015-08-01
J Cell Sci. 2015 Aug 1;128(15):2747-58.
http://hdl.handle.net/20.500.12105/17953
26159735
10.1242/jcs.153940
1477-9137
Journal of cell science
An essential property of the plasma membrane of mammalian cells is its plasticity, which is required for sensing and transmitting of signals, and for accommodating the tensional changes imposed by its environment or its own biomechanics. Caveolae are unique invaginated membrane nanodomains that play a major role in organizing signaling, lipid homeostasis and adaptation to membrane tension. Caveolae are frequently associated with stress fibers, a major regulator of membrane tension and cell shape. In this Commentary, we discuss recent studies that have provided new insights into the function of caveolae and have shown that trafficking and organization of caveolae are tightly regulated by stress-fiber regulators, providing a functional link between caveolae and stress fibers. Furthermore, the tension in the plasma membrane determines the curvature of caveolae because they flatten at high tension and invaginate at low tension, thus providing a tension-buffering system. Caveolae also regulate multiple cellular pathways, including RhoA-driven actomyosin contractility and other mechanosensitive pathways, suggesting that caveolae could couple mechanotransduction pathways to actin-controlled changes in tension through their association with stress fibers. Therefore, we argue here that the association of caveolae with stress fibers could provide an important strategy for cells to deal with mechanical stress.
eng
Caveolae - mechanosensitive membrane invaginations linked to actin filaments.
journal article
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Caveolae - mechanosensitive_J Cell Sci_2015.pdf
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Caveolae - mechanosensitive_J Cell Sci_2015.pdf.txt