2026-04-29T06:16:20Zhttps://repisalud.isciii.es/rest/oai/request
oai:repisalud.isciii.es:20.500.12105/179262024-09-21T23:02:33Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud author Edwards Iii, George author Gamez, Nazaret author Armijo, Enrique author Kramm, Carlos author Morales, Rodrigo author Taylor-Presse, Kathleen author Schulz, Paul E author Soto, Claudio author Moreno-Gonzalez, Ines 2024-02-10T20:02:25Z 2024-02-10T20:02:25Z 2019-10-30 http://hdl.handle.net/10668/15588 http://hdl.handle.net/20.500.12105/17926 31671704 10.3390/cells8111359 2073-4409 Cells Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by loss of motor control due to a wide loss of dopaminergic neurons along the nigro-striatal pathway. Some of the mechanisms that contribute to this cell death are inflammation, oxidative stress, and misfolded alpha-synuclein-induced toxicity. Current treatments are effective at managing the early motor symptoms of the disease, but they become ineffective over time and lead to adverse effects. Previous research using intracerebral stem cell therapy for treatment of PD has provided promising results; however, this method is very invasive and is often associated with unacceptable side effects. In this study, we used an MPTP-injected mouse model of PD and intravenously administered neural precursors (NPs) obtained from mouse embryonic and mesenchymal stem cells. Clinical signs and neuropathology were assessed. Female mice treated with NPs had improved motor function and reduction in the neuroinflammatory response. In terms of safety, there were no tumorigenic formations or any detectable adverse effect after treatment. Our results suggest that peripheral administration of stem cell-derived NPs may be a promising and safe therapy for the recovery of impaired motor function and amelioration of brain pathology in PD. eng Parkinson’s disease Clinical symptoms Inflammation Intravenous Neuronal precursors Stem cells Therapy Peripheral Delivery of Neural Precursor Cells Ameliorates Parkinson's Disease-Associated Pathology. research article