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oai:repisalud.isciii.es:20.500.12105/179022024-11-28T15:22:40Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud author Leuermann, Jonas author Fernández-Gavela, Adrián author Torres-Cubillo, Antonia author Postigo, Sergio author Sánchez-Postigo, Alejandro author Lechuga, Laura M. author Halir, Robert author Molina-Fernández, Íñigo authoraffiliation [Leuermann,J; Halir,R; Molina-Fernández,I] Bionand Center for Nanomedicine and Biotechnology, Málaga, Spain. [Leuermann,J; Torres-Cubillo,A; Sánchez-Postigo,A; Halir,R; Molina-Fernández,I] Department de Ingeniería de Comunicaciones, Universidad de Málaga, ETSI Telecomunicación, Málaga, Spain. [Fernández-Gavela,A] Departamento de Física, Universidad de Oviedo, Oviedo, Spain. [Postigo,S] Department de Ingeniería Mecánica, Universidad de Málaga, Térmica y de Fluidos, Escuela de Ingenierías Industriales, Málaga, Spain. [Lechuga,LM] Nanobiosensors and Bioanalytical Applications Group, Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC, BIST and CIBER-BBN Campus UAB, Barcelona, Spain. 2024-02-10T20:02:02Z 2024-02-10T20:02:02Z 2019-08-23 http://hdl.handle.net/10668/3341 http://hdl.handle.net/20.500.12105/17902 31450817 10.3390/s19173671 1424-8220 Sensors Waveguide-based photonic sensors provide a unique combination of high sensitivity, compact size and label-free, multiplexed operation. Interferometric configurations furthermore enable a simple, fixed-wavelength read-out making them particularly suitable for low-cost diagnostic and monitoring devices. Their limit of detection, i.e., the lowest analyte concentration that can be reliably observed, mainly depends on the sensors response to small refractive index changes, and the noise in the read-out system. While enhancements in the sensors response have been extensively studied, noise optimization has received much less attention. Here we show that order-of-magnitude enhancements in the limit of detection can be achieved through systematic noise reduction, and demonstrate a limit of detection of ∼ 10−8RIU with a silicon nitride sensor operating at telecom wavelengths. eng Biosensors Coherent detection Interferometer Limit of detection Silicon photonics Técnicas biosensibles Límite de detección Optimizing the Limit of Detection of Waveguide-Based Interferometric Biosensor Devices research article