2026-04-27T03:43:08Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/179022024-11-28T15:22:40Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927

00925njm 22002777a 4500 dc Leuermann, Jonas author Fernández-Gavela, Adrián author Torres-Cubillo, Antonia author Postigo, Sergio author Sánchez-Postigo, Alejandro author Lechuga, Laura M. author Halir, Robert author Molina-Fernández, Íñigo author 2019-08-23 Waveguide-based photonic sensors provide a unique combination of high sensitivity, compact size and label-free, multiplexed operation. Interferometric configurations furthermore enable a simple, fixed-wavelength read-out making them particularly suitable for low-cost diagnostic and monitoring devices. Their limit of detection, i.e., the lowest analyte concentration that can be reliably observed, mainly depends on the sensors response to small refractive index changes, and the noise in the read-out system. While enhancements in the sensors response have been extensively studied, noise optimization has received much less attention. Here we show that order-of-magnitude enhancements in the limit of detection can be achieved through systematic noise reduction, and demonstrate a limit of detection of ∼ 10−8RIU with a silicon nitride sensor operating at telecom wavelengths. http://hdl.handle.net/10668/3341 http://hdl.handle.net/20.500.12105/17902 31450817 10.3390/s19173671 1424-8220 Sensors Biosensors Coherent detection Interferometer Limit of detection Silicon photonics Técnicas biosensibles Límite de detección Optimizing the Limit of Detection of Waveguide-Based Interferometric Biosensor Devices