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oai:repisalud.isciii.es:20.500.12105/178942024-05-17T10:03:48Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927

00925njm 22002777a 4500 dc Castellano-Castillo, Daniel author Royo, José Luis author Martínez-Escribano, Ana author Sánchez-Alcoholado, Lidia author Molina-Vega, María author Queipo-Ortuño, María Isabel author Ruiz-Galdon, Maximiliano author J Álvarez-Millán, Juan author Cabezas-Sanchez, Pablo author Reyes-Engel, Armando author Tinahones, Francisco J author Cardona, Fernando author Fernández-García, José Carlos author 2019-07-31 Obesity has been associated with increased risk of presenting hypogonadism. Free testosterone (FT) is the fraction of testosterone that carries out the biological function of testosterone, and is determined from total testosterone (TT) and sex-hormone binding globulin (SHBG) levels. We aimed to study the SHBG polymorphism rs1799941 in a cohort of young non-diabetic obese males to unravel the possible implication of this polymorphism in obesity-related hypogonadism. 212 young ( 3.5 ng/mL and FT ≥ 70 pg/mL; EuG), normal FT hypogonadism (n = 40, TT The rs1799941 frequencies were different among the groups. Higher proportion of the allele (A) was found in HG, compared to EuG and normal FT HG. Among the genotypes, the rare homozygous (AA) were found in the normal FT HG group and higher levels of serum SHBG and lower of FT were observed. The presence of the allele A was related (according to lineal regression models) to an increased of SHBG levels ((GA) β = 3.28; (AA) β = 12.45) and a decreased of FT levels ((GA) β = -9.19; (AA) β = -18.52). The presence of the allele (A) increased the risk of presenting HG compared to normal FT HG (OR = 2.54). The rs1799941 of the SHBG gene can partially determine the presence of obesity-related hypogonadism in young non-diabetic males and whether these subjects have normal FT HG. 10.3390/jcm8081136 2077-0383 Journal of clinical medicine http://hdl.handle.net/10668/14351 31370189 http://hdl.handle.net/20.500.12105/17894 SHBG Free testosterone Hypogonadism Obesity Polymorphism rs1799941 Effects of SHBG rs1799941 Polymorphism on Free Testosterone Levels and Hypogonadism Risk in Young Non-Diabetic Obese Males.