2026-05-22T00:01:09Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/178862024-02-10T20:01:50Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud
author
Ramos-Molina, Bruno
author
Sánchez-Alcoholado, Lidia
author
Cabrera-Mulero, Amanda
author
Lopez-Dominguez, Raul
author
Carmona-Saez, Pedro
author
Garcia-Fuentes, Eduardo
author
Moreno-Indias, Isabel
author
Tinahones, Francisco J
2024-02-10T20:01:50Z
2024-02-10T20:01:50Z
2019-07-03
10.3389/fgene.2019.00613
1664-8021
Frontiers in genetics
http://hdl.handle.net/10668/14288
31333715
http://hdl.handle.net/20.500.12105/17886
Objective: Obesity and obesity-related metabolic diseases are characterized by gut microbiota and epigenetic alterations. Recent insight has suggested the existence of a crosstalk between the gut microbiome and the epigenome. However, the possible link between alterations in gut microbiome composition and epigenetic marks in obesity has been not explored yet. The aim of this work is to establish a link between the gut microbiota and the global DNA methylation profile in a group of obese subjects and to report potential candidate genes that could be epigenetically regulated by gut microbiota in adipose tissue. Methods: Gut microbiota composition was analyzed in DNA stool samples from 45 obese subjects by 16S ribosomal RNA (rRNA) gene sequencing. Twenty patients were selected based on their Bacteroidetes-to-Firmicutes ratio (BFR): HighBFR group (BFR > 2.5, n = 10) and LowBFR group (BFR 2.5, n = 10) and LowBFR group (BFR
eng
Adipose tissue
Epigenetics
Gut microbiota
Methylation
Obesity
Gut Microbiota Composition Is Associated With the Global DNA Methylation Pattern in Obesity.
research article