2026-07-21T11:39:41Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/178862024-02-10T20:01:50Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927

00925njm 22002777a 4500 dc Ramos-Molina, Bruno author Sánchez-Alcoholado, Lidia author Cabrera-Mulero, Amanda author Lopez-Dominguez, Raul author Carmona-Saez, Pedro author Garcia-Fuentes, Eduardo author Moreno-Indias, Isabel author Tinahones, Francisco J author 2019-07-03 Objective: Obesity and obesity-related metabolic diseases are characterized by gut microbiota and epigenetic alterations. Recent insight has suggested the existence of a crosstalk between the gut microbiome and the epigenome. However, the possible link between alterations in gut microbiome composition and epigenetic marks in obesity has been not explored yet. The aim of this work is to establish a link between the gut microbiota and the global DNA methylation profile in a group of obese subjects and to report potential candidate genes that could be epigenetically regulated by gut microbiota in adipose tissue. Methods: Gut microbiota composition was analyzed in DNA stool samples from 45 obese subjects by 16S ribosomal RNA (rRNA) gene sequencing. Twenty patients were selected based on their Bacteroidetes-to-Firmicutes ratio (BFR): HighBFR group (BFR > 2.5, n = 10) and LowBFR group (BFR 2.5, n = 10) and LowBFR group (BFR 10.3389/fgene.2019.00613 1664-8021 Frontiers in genetics http://hdl.handle.net/10668/14288 31333715 http://hdl.handle.net/20.500.12105/17886 Adipose tissue Epigenetics Gut microbiota Methylation Obesity Gut Microbiota Composition Is Associated With the Global DNA Methylation Pattern in Obesity.