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00925njm 22002777a 4500 dc Julibert, Alicia author Bibiloni, Maria Del Mar author Bouzas, Cristina author Martínez-González, Miguel Ángel author Salas-Salvadó, Jordi author Corella, Dolores author Zomeño, Maria Dolors author Romaguera, Dora author Vioque, Jesús author Alonso-Gómez, Ángel M author Wärnberg, Julia author Martínez, J Alfredo author Serra-Majem, Luís author Estruch, Ramon author Tinahones, Francisco J author Lapetra, José author Pintó, Xavier author Lopez-Miranda, José author García-Molina, Laura author Gaforio, José Juan author Matía-Martín, Pilar author Daimiel, Lidia author Martín-Sánchez, Vicente author Vidal, Josep author Vázquez, Clotilde author Ros, Emili author Toledo, Estefanía author Becerra-Tomás, Nerea author Pórtoles, Olga author Pérez-Vega, Karla A author Fiol, Miquel author Torres-Collado, Laura author Tojal-Sierra, Lucas author Carabaño-Moral, Rosa author Abete, Itziar author Sanchez-Villegas, Almudena author Casas, Rosa author Bernal-López, María Rosa author Santos-Lozano, José Manuel author Galera, Ana author Ugarriza, Lucía author Ruiz-Canela, Miguel author Babio, Nancy author Coltell, Oscar author Schröder, Helmut author Konieczna, Jadwiga author Orozco-Beltrán, Domingo author Sorto-Sánchez, Carolina author Eguaras, Sonia author Barrubés, Laura author Fitó, Montserrat author Tur, Josep A author Predimed-Plus Investigators author 2019-06-29 Background: The effect of dietary fat intake on the metabolic syndrome (MetS) and in turn on cardiovascular disease (CVD) remains unclear in individuals at high CVD risk. Objective: To assess the association between fat intake and MetS components in an adult Mediterranean population at high CVD risk. Design: Baseline assessment of nutritional adequacy in participants (n = 6560, men and women, 55-75 years old, with overweight/obesity and MetS) in the PREvención con DIeta MEDiterránea (PREDIMED)-Plus randomized trial. Methods: Assessment of fat intake (total fat, monounsatured fatty acids: MUFA, polyunsaturated fatty acids: PUFA, saturated fatty acids: SFA, trans-fatty acids: trans-FA, linoleic acid, α-linolenic acid, and ω-3 FA) using a validated food frequency questionnaire, and diet quality using 17-item Mediterranean dietary questionnaire and fat quality index (FQI). Results: Participants in the highest quintile of total dietary fat intake showed lower intake of energy, carbohydrates, protein and fiber, but higher intake of PUFA, MUFA, SFA, TFA, LA, ALA and ω-3 FA. Differences in MetS components were found according to fat intake. Odds (5th vs. 1st quintile): hyperglycemia: 1.3-1.6 times higher for total fat, MUFA, SFA and ω-3 FA intake; low high-density lipoprotein cholesterol (HDL-c): 1.2 higher for LA; hypertriglyceridemia: 0.7 lower for SFA and ω-3 FA intake. Conclusions: Dietary fats played different role on MetS components of high CVD risk patients. Dietary fat intake was associated with higher risk of hyperglycemia. 10.3390/nu11071493 2072-6643 Nutrients http://hdl.handle.net/10668/14204 http://hdl.handle.net/20.500.13003/16097 31261967 L2002354203 2-s2.0-85069267692 http://hdl.handle.net/20.500.12105/17884 478885400086 Mediterranean diet Cardiovascular disease risk Dietary fat Fat intake Fatty acids Total and Subtypes of Dietary Fat Intake and Its Association with Components of the Metabolic Syndrome in a Mediterranean Population at High Cardiovascular Risk