2026-04-29T04:08:46Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/178732024-02-10T20:01:37Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927

00925njm 22002777a 4500 dc Breiteneder, Heimo author Diamant, Zuzana author Eiwegger, Thomas author Fokkens, Wytske J author Traidl-Hoffmann, Claudia author Nadeau, Kari author O'Hehir, Robyn E author O'Mahony, Liam author Pfaar, Oliver author Torres, Maria J author Wang, De Yun author Zhang, Luo author Akdis, Cezmi A author 2019-06-04 The specialties of allergy and clinical immunology have entered the era of precision medicine with the stratification of diseases into distinct disease subsets, specific diagnoses, and targeted treatment options, including biologicals and small molecules. This article reviews recent developments in research and patient care and future trends in the discipline. The section on basic mechanisms of allergic diseases summarizes the current status and defines research needs in structural biology, type 2 inflammation, immune tolerance, neuroimmune mechanisms, role of the microbiome and diet, environmental factors, and respiratory viral infections. In the section on diagnostic challenges, clinical trials, precision medicine and immune monitoring of allergic diseases, asthma, allergic and nonallergic rhinitis, and new approaches to the diagnosis and treatment of drug hypersensitivity reactions are discussed in further detail. In the third section, unmet needs and future research areas for the treatment of allergic diseases are highlighted with topics on food allergy, biologics, small molecules, and novel therapeutic concepts in allergen-specific immunotherapy for airway disease. Unknowns and future research needs are discussed at the end of each subsection. http://hdl.handle.net/10668/13915 http://hdl.handle.net/20.500.12105/17873 31056763 10.1111/all.13851 1398-9995 Allergy Allergy Exposome Microbiome Neuroimmune Respiratory viral infections Future research trends in understanding the mechanisms underlying allergic diseases for improved patient care.