2026-04-29T01:00:02Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/178542024-09-21T23:37:10Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927

00925njm 22002777a 4500 dc Garcia-Diaz, Beatriz author Bachelin, Corinne author Coulpier, Fanny author Gerschenfeld, Gaspard author Deboux, Cyrille author Zujovic, Violetta author Charnay, Patrick author Topilko, Piotr author Baron-Van Evercooren, Anne author 2019-04-22 Schwann cells (SC) enter the central nervous system (CNS) in pathophysiological conditions. However, how SC invade the CNS to remyelinate central axons remains undetermined. We studied SC migratory behavior ex vivo and in vivo after exogenous transplantation in the demyelinated spinal cord. The data highlight for the first time that SC migrate preferentially along blood vessels in perivascular extracellular matrix (ECM), avoiding CNS myelin. We demonstrate in vitro and in vivo that this migration route occurs by virtue of a dual mode of action of Eph/ephrin signaling. Indeed, EphrinB3, enriched in myelin, interacts with SC Eph receptors, to drive SC away from CNS myelin, and triggers their preferential adhesion to ECM components, such as fibronectin via integrinβ1 interactions. This complex interplay enhances SC migration along the blood vessel network and together with lesion-induced vascular remodeling facilitates their timely invasion of the lesion site. These novel findings elucidate the mechanism by which SC invade and contribute to spinal cord repair. http://hdl.handle.net/10668/13866 http://hdl.handle.net/20.500.12105/17854 31011859 10.1007/s00401-019-02011-1 1432-0533 Acta neuropathologica Blood vessels Central nervous system EphrinB3 Migration Schwann cells Blood vessels guide Schwann cell migration in the adult demyelinated CNS through Eph/ephrin signaling.