2026-04-29T04:52:22Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/178452024-09-21T22:59:05Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud
author
Gomez-Huelgas, Ricardo
author
Ruiz-Nava, Josefina
author
Santamaria-Fernandez, Sonia
author
Vargas-Candela, Antonio
author
Alarcon-Martin, Ana Victoria
author
Tinahones, Francisco J
author
Bernal-Lopez, M Rosa
2024-02-10T20:01:13Z
2024-02-10T20:01:13Z
2019-04-09
http://hdl.handle.net/10668/13970
http://hdl.handle.net/20.500.12105/17845
31093012
10.1155/2019/4165260
1466-1861
Mediators of inflammation
For the metabolically healthy obese (MHO) subjects, it is unclear whether weight loss provides cardiometabolic benefits. Our objective was to evaluate whether changes in adipokine and inflammatory biomarker levels were related to lifestyle modification (with Mediterranean diet and physical exercise program). 115 women (35-55 years) with BMI of 30-40 kg/m2 and ≤1 metabolic syndrome criteria were included. After a 2-year intervention, participants were classified by percent weight loss: Group 1, The final sample comprised 67 women. 23 (38.3%) lost Weight loss reduces inflammatory biomarkers in the MHO but induces a deterioration in the adipokine profile, which does not improve with diet and exercise intervention. These findings allow us to clarify mechanisms behind inflammation and metabolic disorder genesis so as to prevent development of obesity-associated comorbidities.
eng
Impact of Intensive Lifestyle Modification on Levels of Adipokines and Inflammatory Biomarkers in Metabolically Healthy Obese Women.
research article