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oai:repisalud.isciii.es:20.500.12105/178452024-09-21T22:59:05Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927

00925njm 22002777a 4500 dc Gomez-Huelgas, Ricardo author Ruiz-Nava, Josefina author Santamaria-Fernandez, Sonia author Vargas-Candela, Antonio author Alarcon-Martin, Ana Victoria author Tinahones, Francisco J author Bernal-Lopez, M Rosa author 2019-04-09 For the metabolically healthy obese (MHO) subjects, it is unclear whether weight loss provides cardiometabolic benefits. Our objective was to evaluate whether changes in adipokine and inflammatory biomarker levels were related to lifestyle modification (with Mediterranean diet and physical exercise program). 115 women (35-55 years) with BMI of 30-40 kg/m2 and ≤1 metabolic syndrome criteria were included. After a 2-year intervention, participants were classified by percent weight loss: Group 1, The final sample comprised 67 women. 23 (38.3%) lost Weight loss reduces inflammatory biomarkers in the MHO but induces a deterioration in the adipokine profile, which does not improve with diet and exercise intervention. These findings allow us to clarify mechanisms behind inflammation and metabolic disorder genesis so as to prevent development of obesity-associated comorbidities. http://hdl.handle.net/10668/13970 http://hdl.handle.net/20.500.12105/17845 31093012 10.1155/2019/4165260 1466-1861 Mediators of inflammation Impact of Intensive Lifestyle Modification on Levels of Adipokines and Inflammatory Biomarkers in Metabolically Healthy Obese Women.