2026-06-14T03:31:21Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/178312024-09-21T22:32:54Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927col_20.500.12105_16971col_20.500.12105_16983
Repisalud
author
García-Marchena, Nuria
author
Barrera, Marta
author
Mestre-Pintó, Joan Ignasi
author
Araos, Pedro
author
Serrano, Antonia
author
Pérez-Mañá, Clara
author
Papaseit, Esther
author
Fonseca, Francina
author
Ruiz, Juan Jesús
author
Rodríguez de Fonseca, Fernando
author
Farré, Magí
author
Pavón, Francisco Javier
author
Torrens, Marta
2024-02-10T20:00:58Z
2024-02-10T20:00:58Z
2019-03-14
10.1371/journal.pone.0213791
1932-6203
PloS one
http://hdl.handle.net/10668/13707
30870525
http://hdl.handle.net/20.500.12105/17831
Major depressive disorder (MDD) is the most prevalent comorbid mental disorder among people with substance use disorders. The MDD can be both primary and substance-induced and its accurate diagnosis represents a challenge for clinical practice and treatment response. Recent studies reported alterations in the circulating expression of inflammatory mediators in patients with psychiatric disorders, including those related to substance use. The aim of the study was to explore TNF-α, IL-1β, CXCL12, CCL2, CCL11 (eotaxin-1) and CX3CL1 (fractalkine) as potential biomarkers to identify comorbid MDD and to distinguish primary MDD from substance-induced MDD in patients with substance disorders. Patients diagnosed with cocaine (CUD, n = 64) or alcohol (AUD, n = 65) use disorders with/without MDD were recruited from outpatient treatment programs [CUD/non-MDD (n = 31); CUD/primary MDD (n = 18); CUD/cocaine-induced MDD (N = 15); AUD/non-MDD (n = 27); AUD/primary MDD (n = 16) and AUD/alcohol-induced MDD (n = 22)]. Sixty-two healthy subjects were also recruited as control group. Substance and mental disorders were assessed according to "Diagnostic and Statistical Manual of Mental Disorders, 4th edition, text revision" (DSM-IV-TR) and a blood sample was collected for determinations in the plasma. The cocaine group showed lower TNF-α (p
eng
Inflammatory mediators and dual depression: Potential biomarkers in plasma of primary and substance-induced major depression in cocaine and alcohol use disorders.
research article