2026-04-27T01:59:09Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/178222024-02-10T20:00:49Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud
author
Lucena, María Isabel
author
García-Martín, Elena
author
Daly, Ann K
author
Blanca, Miguel
author
Andrade, Raúl J
author
Agúndez, José A G
2024-02-10T20:00:49Z
2024-02-10T20:00:49Z
2019-02-28
1664-8021
http://hdl.handle.net/10668/13713
http://hdl.handle.net/20.500.12105/17822
30873208
10.3389/fgene.2019.00134
Frontiers in genetics
Purpose: The etiopathogenesis of drug-induced liver injury (DILI) is still far from being elucidated. This study aims to the study of genetic variations in DILI, related to the drug target, and specifically in the genes coding for the cyclooxygenase enzymes. Methods: By using Next-generation Sequencing we analyzed the genes coding for COX enzymes (PTGS1 and PTGS2) in 113 individuals, 13 of which were patients with DILI caused by COX-inhibitors. Results: The key findings of the study are the increased frequency, among DILI patients, of SNPs causing alterations in transcription factor binding sites and non-synonymous PTGS gene variants, as compared to control subjects. Moreover, the association with non-synonymous SNPs was exclusive of DILI patients with late-onset (50 days or more) Pc
eng
COX1
COX2
PTGS1
PTGS2
Drug-induced liver injury
Next generation sequencing
Next-Generation Sequencing of PTGS Genes Reveals an Increased Frequency of Non-synonymous Variants Among Patients With NSAID-Induced Liver Injury.
research article