2026-04-27T03:42:43Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/178222024-02-10T20:00:49Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927

00925njm 22002777a 4500 dc Lucena, María Isabel author García-Martín, Elena author Daly, Ann K author Blanca, Miguel author Andrade, Raúl J author Agúndez, José A G author 2019-02-28 Purpose: The etiopathogenesis of drug-induced liver injury (DILI) is still far from being elucidated. This study aims to the study of genetic variations in DILI, related to the drug target, and specifically in the genes coding for the cyclooxygenase enzymes. Methods: By using Next-generation Sequencing we analyzed the genes coding for COX enzymes (PTGS1 and PTGS2) in 113 individuals, 13 of which were patients with DILI caused by COX-inhibitors. Results: The key findings of the study are the increased frequency, among DILI patients, of SNPs causing alterations in transcription factor binding sites and non-synonymous PTGS gene variants, as compared to control subjects. Moreover, the association with non-synonymous SNPs was exclusive of DILI patients with late-onset (50 days or more) Pc 1664-8021 http://hdl.handle.net/10668/13713 http://hdl.handle.net/20.500.12105/17822 30873208 10.3389/fgene.2019.00134 Frontiers in genetics COX1 COX2 PTGS1 PTGS2 Drug-induced liver injury Next generation sequencing Next-Generation Sequencing of PTGS Genes Reveals an Increased Frequency of Non-synonymous Variants Among Patients With NSAID-Induced Liver Injury.