2026-08-29T12:38:51Zhttps://repisalud.isciii.es/rest/oai/request
oai:repisalud.isciii.es:20.500.12105/177932024-09-21T22:44:34Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud author Coín-Aragüez, Leticia author Pavón, Francisco Javier author Contreras, Alba author Gentile, Adriana-Mariel author Lhamyani, Said author De Diego-Otero, Yolanda author Casado, Yolanda author Oliva Olivera, Wilfredo author Olveira, Gabriel author Tinahones, Francisco J author Pérez Costillas, Lucía author El Bekay, Rajaa 2024-02-09T16:00:15Z 2024-02-09T16:00:15Z 2018-11-30 10.1038/s41598-018-35759-9 2045-2322 Scientific reports http://hdl.handle.net/10668/13269 30504920 http://hdl.handle.net/20.500.12105/17793 Psychiatric disorders have been widely reported to be associated with systemic inflammation upregulation and adiposity. However, there are no data that link adipose tissue inflammation to these mental disorders. The analysis of adipokines and inflammation-related markers in adipose tissue could help to elucidate the potential association between obesity and mental health. An observational study was conducted in samples of patients consisting of non-obese and obese subjects, who were diagnosed with anxiety or mood disorders. Gene expression of adiponectin (ADIPOQ), leptin (LEP) and inflammatory markers (IL6, IL1B, TNF, CCL2, CSF3, ITGAM, and PLAUR) were determined in visceral (VAT) and subcutaneous (SAT) adipose tissues. Our results showed that the gene expression of adipokines and inflammation-related markers was higher in the VAT and SAT of obese subjects compared with non-obese subjects. Regarding mental disorders, all the inflammatory genes in the VAT were significantly higher in non-obese subjects with anxiety or mood disorders than in subjects without mental disorders, except for TNF and ITGAM. Additionally, IL6 expression was significantly lower in SAT. In contrast, obese patients diagnosed with anxiety or mood disorders only showed significantly lower expression levels of IL1B in VAT and ADIPOQ in SAT when compared with obese subjects without mental disorders. These data suggest the potential involvement of VAT inflammation in anxiety and mood disorders, involving complex mechanisms which are strongly affected by obesity. eng Inflammatory gene expression in adipose tissue according to diagnosis of anxiety and mood disorders in obese and non-obese subjects. research article