2026-07-23T19:37:08Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/176952025-01-13T12:49:10Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609col_20.500.12105_25179

00925njm 22002777a 4500 dc Ruiz-López, María José author Aguilera-Sepúlveda, Pilar author Cebrián-Camisón, Sonia author Figuerola, Jordi author Magallanes, Sergio author Varona Fernandez, Sarai author Cuesta de la Plaza, Isabel author Cano-Gómez, Cristina author Sánchez-Mora, Patricia author Camacho, Juan author Sánchez-Peña, Carolina author Marchena, Francisco José author Ameyugo, Ulises author Ruíz, Santiago author Sánchez-Seco, María Paz author Agüero, Montserrat author Jiménez-Clavero, Miguel Ángel author Fernández-Pinero, Jovita author Vazquez, Ana author 2023-12-01 West Nile Virus (WNV) is a mosquito vector-borne zoonosis with an increasing incidence in Europe that has become a public health concern. In Spain, although local circulation has been known for decades, until 2020, when a large outbreak occurred, West Nile Virus cases were scarce and mostly occurred in southern Spain. Since then, there have been new cases every year and the pathogen has spread to new regions. Thus, monitoring of circulating variants and lineages plays a fundamental role in understanding WNV evolution, spread and dynamics. In this study, we sequenced WNV consensus genomes from mosquito pools captured in 2022 as part of a newly implemented surveillance program in southern Spain and compared it to other European, African and Spanish sequences. Characterization of WNV genomes in mosquitoes captured in 2022 reveals the co-circulation of two WNV lineage 1 variants, the one that caused the outbreak in 2020 and another variant that is closely related to variants reported in Spain in 2012, France in 2015, Italy in 2021-2022 and Senegal in 2012-2018. The geographic distribution of these variants indicates that WNV L1 dynamics in southern Europe include an alternating dominance of variants in some territories. Viruses. 2023 Dec 1;15(12):2372. 10.3390/v15122372 1999-4915 Viruses 38140614 http://hdl.handle.net/20.500.12105/17695 Culex Flavivirus Genetic variants Spain Vector-borne diseases WNV lineage 1 Zoonosis Re-Emergence of a West Nile Virus (WNV) Variant in South Spain with Rapid Spread Capacity