2026-08-29T14:04:58Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/176792024-11-29T19:59:11Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud
author
Rigual, María Del Mar
author
Sánchez Sánchez, Paula
author
Djouder, Nabil
funder
Fundación BBVA
funder
Ministerio de Ciencia (España)
2024-02-09T09:08:03Z
2024-02-09T09:08:03Z
2023-02
Trends Cancer . 2023 ;9(2):140-157
10.1016/j.trecan.2022.10.005
2405-8025
Trends in cancer
36347768
http://hdl.handle.net/20.500.12105/17679
The liver is the largest organ of the mammalian body and has the remarkable ability to fully regenerate in order to maintain tissue homeostasis. The adult liver consists of hexagonal lobules, each with a central vein surrounded by six portal triads localized in the lobule border containing distinct parenchymal and nonparenchymal cells. Because the liver is continuously exposed to diverse stress signals, several sophisticated regenerative processes exist to restore its functional status following impairment. However, these stress signals can affect the liver's capacity to regenerate and may lead to the development of hepatocellular carcinoma (HCC), one of the most aggressive liver cancers. Here, we review the mechanisms of hepatic regeneration and their potential to influence HCC development.
eng
Is liver regeneration key in hepatocellular carcinoma development?
journal article
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URL
https://repisalud.isciii.es/bitstreams/846678ca-591e-4856-814b-5903d8835098/download
File
MD5
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application/vnd.openxmlformats-officedocument.wordprocessingml.document
Is liver regeneration_2022.docx
URL
https://repisalud.isciii.es/bitstreams/7015f0ec-409d-4478-b3b3-d9fd0aecea13/download
File
MD5
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text/plain
Is liver regeneration_2022.docx.txt