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oai:repisalud.isciii.es:20.500.12105/176792024-11-29T19:59:11Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597

00925njm 22002777a 4500 dc Rigual, María Del Mar author Sánchez Sánchez, Paula author Djouder, Nabil author 2023-02 The liver is the largest organ of the mammalian body and has the remarkable ability to fully regenerate in order to maintain tissue homeostasis. The adult liver consists of hexagonal lobules, each with a central vein surrounded by six portal triads localized in the lobule border containing distinct parenchymal and nonparenchymal cells. Because the liver is continuously exposed to diverse stress signals, several sophisticated regenerative processes exist to restore its functional status following impairment. However, these stress signals can affect the liver's capacity to regenerate and may lead to the development of hepatocellular carcinoma (HCC), one of the most aggressive liver cancers. Here, we review the mechanisms of hepatic regeneration and their potential to influence HCC development. Trends Cancer . 2023 ;9(2):140-157 10.1016/j.trecan.2022.10.005 2405-8025 Trends in cancer 36347768 http://hdl.handle.net/20.500.12105/17679 Is liver regeneration key in hepatocellular carcinoma development?