2026-04-29T02:18:39Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/176762024-11-29T16:00:29Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud
author
Garrido, Amanda
author
Djouder, Nabil
funder
Comunidad de Madrid (España)
funder
Ministerio de Economía e Innovación (España)
funder
European Foundation for the Study of Diabetes
2024-02-09T08:47:37Z
2024-02-09T08:47:37Z
2021-01
Trends Cancer . 2021;7(1):29-36
http://hdl.handle.net/20.500.12105/17676
32917550
10.1016/j.trecan.2020.08.005
2405-8025
Trends in cancer
The liver is one of the major metabolic organs in the body, susceptible to injury caused by various factors. In response to injury, sophisticated mechanisms are engaged to repair and regenerate the damaged liver, preventing its failure. When the damage is chronic, regeneration goes awry, impairing liver function and causing cirrhosis. Hence, cirrhosis may rather be a protective response to injury, where wound-healing processes are set to primarily repair the damaged liver. Although cirrhosis is clinically considered a risk factor for hepatocellular carcinoma (HCC), comprehensive population-based studies demonstrate a very modest incidence, refuting the idea that cirrhosis progresses to HCC. Here, we discuss and shed light on the provocative question of whether cirrhosis predisposes to HCC.
eng
Cirrhosis: A Questioned Risk Factor for Hepatocellular Carcinoma.
journal article
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URL
https://repisalud.isciii.es/bitstreams/35a715d6-0beb-4470-8357-9bc566aaef9a/download
File
MD5
b1e310591b29fb787bc0b7a842a5ed62
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application/vnd.openxmlformats-officedocument.wordprocessingml.document
CirrhosisQuestioned_2020.docx
URL
https://repisalud.isciii.es/bitstreams/97c6fb00-f3a9-4f34-9f44-e337565a9f44/download
File
MD5
e88c5ee49219aec3fe16e4fae9ae9821
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text/plain
CirrhosisQuestioned_2020.docx.txt