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oai:repisalud.isciii.es:20.500.12105/176762024-11-29T16:00:29Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597

00925njm 22002777a 4500 dc Garrido, Amanda author Djouder, Nabil author 2021-01 The liver is one of the major metabolic organs in the body, susceptible to injury caused by various factors. In response to injury, sophisticated mechanisms are engaged to repair and regenerate the damaged liver, preventing its failure. When the damage is chronic, regeneration goes awry, impairing liver function and causing cirrhosis. Hence, cirrhosis may rather be a protective response to injury, where wound-healing processes are set to primarily repair the damaged liver. Although cirrhosis is clinically considered a risk factor for hepatocellular carcinoma (HCC), comprehensive population-based studies demonstrate a very modest incidence, refuting the idea that cirrhosis progresses to HCC. Here, we discuss and shed light on the provocative question of whether cirrhosis predisposes to HCC. Trends Cancer . 2021;7(1):29-36 http://hdl.handle.net/20.500.12105/17676 32917550 10.1016/j.trecan.2020.08.005 2405-8025 Trends in cancer Cirrhosis: A Questioned Risk Factor for Hepatocellular Carcinoma.