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00925njm 22002777a 4500 dc Grazioso, Tatiana P author Djouder, Nabil author 2023-04-21 In their latest article, Seki and colleagues investigate the potential role of cold as a therapeutical option to treat various cancer types, including even clinically untreatable cancers such as pancreatic cancers. The authors suggest that cold exposure may have a tumor-suppressive effect mediated by the activation of brown adipose tissue (BAT), in charge of dissipating heat through non-shivering thermogenesis. In this regard, circulating blood glucose is decreased, restricting the tumor glucose uptake, which is redistributed, favoring BAT uptake to fuel thermogenesis.1. iScience . 2023;26(4):106511. 10.1016/j.isci.2023.106511 2589-0042 iScience 37091251 http://hdl.handle.net/20.500.12105/17672 A mechanistic view of the use of cold temperature in the treatment of cancer.