2026-06-14T06:44:39Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/176562024-11-29T23:27:47Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud
author
Viera, Alberto
author
Berenguer, Inés
author
Ruiz-Torres, Miguel
author
Gómez, Rocío
author
Guajardo, Andrea
author
Barbero, José Luis
author
Losada, Ana
author
Suja, José A
funder
Ministerio de Ciencia e Innovación (España)
funder
Instituto de Salud Carlos III
funder
Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España)
2024-02-08T17:27:57Z
2024-02-08T17:27:57Z
2020-06-04
EMBO Rep . 2020;21(6):e49273.
10.15252/embr.201949273
1469-3178
EMBO reports
32285610
http://hdl.handle.net/20.500.12105/17656
Cohesin cofactors regulate the loading, maintenance, and release of cohesin complexes from chromosomes during mitosis but little is known on their role during vertebrate meiosis. One such cofactor is PDS5, which exists as two paralogs in somatic and germline cells, PDS5A and PDS5B, with unclear functions. Here, we have analyzed their distribution and functions in mouse spermatocytes. We show that simultaneous excision of Pds5A and Pds5B results in severe defects during early prophase I while their individual depletion does not, suggesting their functional redundancy. Shortened axial/lateral elements and a reduction of early recombination nodules are observed after the strong depletion of PDS5A/B proteins. Moreover, telomere integrity and their association to the nuclear envelope are severely compromised. As these defects occur without detectable reduction in chromosome-bound cohesin, we propose that the dynamic behavior of the complex, mediated by PDS5 proteins, is key for successful completion of meiotic prophase I.
eng
PDS5 proteins regulate the length of axial elements and telomere integrity during male mouse meiosis.
journal article
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URL
https://repisalud.isciii.es/bitstreams/8b74a372-4e1d-4a34-a858-b1fb91a05e15/download
File
MD5
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application/pdf
PDS5proteinsregulate_2020.pdf
URL
https://repisalud.isciii.es/bitstreams/0c018591-875d-498d-a0a2-0b45665042e0/download
File
MD5
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text/plain
PDS5proteinsregulate_2020.pdf.txt