2026-04-28T22:57:02Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/176522024-09-21T10:53:53Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Ayoub, Nabieh
author
Jeyasekharan, Anand D
author
Bernal, Juan A
author
Venkitaraman, Ashok R
2024-02-08T16:33:24Z
2024-02-08T16:33:24Z
2009-05-15
Cell Cycle. 2009 May 15;8(10):1494-500.
http://hdl.handle.net/20.500.12105/17652
19377276
10.4161/cc.8.10.8501
1551-4005
Cell cycle (Georgetown, Tex.)
The dynamics of chromatin-associated proteins control the accessibility of DNA to essential biological transactions like transcription, replication, recombination and repair. Here, we briefly outline what is known about the chromatin changes that occur during the cellular response to DNA breakage, focusing on our recent findings revealing that the chromatin factor HP1beta is mobilized within seconds after DNA damage by an unrecognized signaling cascade mediated by casein kinase 2 (CK2) phosphorylation, paving the way for histone H2AX phosphorylation. We also show here that HP1beta mobilization is neither associated with histone H3 modification on Ser10, an alteration proposed to assist in HP1 ejection from chromatin, nor with evidence of a physical interaction between HP1beta and the CK2 regulatory subunit. Interestingly, following its rapid mobilization, we find that HP1beta gradually re-accumulates on damaged chromatin over a longer time period, suggesting that temporal changes in HP1beta dynamics and interaction with chromatin may assist in different stages of the cellular response to DNA breakage.
eng
Paving the way for H2AX phosphorylation: chromatin changes in the DNA damage response.
journal article
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URL
https://repisalud.isciii.es/bitstreams/879efdf4-d042-43f4-9ed9-78c899cc9759/download
File
MD5
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application/pdf
Paving the way for H2AX_Cell Cycle_2009.pdf
URL
https://repisalud.isciii.es/bitstreams/681bc8d9-cbe4-4e8e-bb16-de5f1db2cef7/download
File
MD5
bc440f938eff61c11fea6773ef891227
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text/plain
Paving the way for H2AX_Cell Cycle_2009.pdf.txt