2026-06-14T03:44:06Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/176482024-11-28T15:16:50Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927col_20.500.12105_16961col_20.500.12105_16967col_20.500.12105_16968col_20.500.12105_16969col_20.500.12105_16982col_20.500.12105_16983col_20.500.12105_16989
Repisalud
author
Sánchez-Villegas, Almudena
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Álvarez-Pérez, Jacqueline
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Toledo, Estefanía
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Salas-Salvadó, Jordi
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Ortega-Azorín, Carolina
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Zomeño, Maria Dolores
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Vioque, Jesús
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Martínez, Jose Alfredo
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Romaguera, Dora
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Pérez-López, Jessica
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López-Miranda, José
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Estruch, Ramón
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Bueno-Cavanillas, Aurora
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Arós, Fernando
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Tur, Josep A
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Tinahones, Francisco J
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Lecea, Oscar
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Martín, Vicente
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Ortega-Calvo, M
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Vázquez, Clotilde
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Pintó, Xavier
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Vidal, Josep
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Daimiel, Lidia
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Delgado-Rodríguez, Miguel
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Matía, Pilar
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Corella, Dolores
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Díaz-López, Andrés
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Babio, Nancy
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Muñoz, Miguel Ángel
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Fitó, Montserrat
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García de la Hera, Manoli
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Abete, Itziar
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García-Rios, Antonio
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Ros, Emilio
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Ruíz-Canela, Miguel
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Martínez-González, Miguel Ángel
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Izquierdo, Marisol
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Serra-Majem, Lluis
2024-02-08T14:42:09Z
2024-02-08T14:42:09Z
2018-12-18
10.3390/nu10122000
2072-6643
Nutrients
http://hdl.handle.net/10668/13332http://hdl.handle.net/20.500.13003/8986
30567286
L625530871
2-s2.0-85058901912
http://hdl.handle.net/20.500.12105/17648
455073200181
Background: The aim of this analysis was to ascertain the type of relationship between fish and seafood consumption, omega-3 polyunsaturated fatty acids (-3 PUFA) intake, and depression prevalence. Methods: Cross-sectional analyses of the PREDIMED-Plus trial. Fish and seafood consumption and -3 PUFA intake were assessed through a validated food-frequency questionnaire. Self-reported life-time medical diagnosis of depression or use of antidepressants was considered as outcome. Depressive symptoms were collected by the Beck Depression Inventory-II. Logistic regression models were used to estimate the association between seafood products and -3 PUFA consumption and depression. Multiple linear regression models were fitted to assess the association between fish and long-chain (LC) -3 PUFA intake and depressive symptoms. Results: Out of 6587 participants, there were 1367 cases of depression. Total seafood consumption was not associated with depression. The odds ratios (ORs) (95% confidence intervals (CIs)) for the 2nd, 3rd, and 4th quintiles of consumption of fatty fish were 0.77 (0.63-0.94), 0.71 (0.58-0.87), and 0.78 (0.64-0.96), respectively, and p for trend = 0.759. Moderate intake of total LC -3 PUFA (approximately 0.5-1 g/day) was significantly associated with a lower prevalence of depression. Conclusion: In our study, moderate fish and LC -3 PUFA intake, but not high intake, was associated with lower odds of depression suggesting a U-shaped relationship.
eng
Depression
Docosahexaenoic acid
Eicosapentaenoic acid
Fish
Omega-3
Seafood Consumption, Omega-3 Fatty Acids Intake, and Life-Time Prevalence of Depression in the PREDIMED-Plus Trial.
research article