2026-06-14T03:37:46Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/176292024-09-21T20:24:56Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927col_20.500.12105_16961

00925njm 22002777a 4500 dc Miranda, Jezid author Simões, Rui V author Paules, Cristina author Cañueto, Daniel author Pardo-Cea, Miguel A author García-Martín, María L author Crovetto, Francesca author Fuertes-Martin, Rocio author Domenech, Monica author Gómez-Roig, María D author Eixarch, Elisenda author Estruch, Ramon author Hansson, Stefan R author Amigó, Nuria author Cañellas, Nicolau author Crispi, Fatima author Gratacós, Eduard author 2018-09-11 Fetal growth may be impaired by poor placental function or maternal conditions, each of which can influence the transfer of nutrients and oxygen from the mother to the developing fetus. Large-scale studies of metabolites (metabolomics) are key to understand cellular metabolism and pathophysiology of human conditions. Herein, maternal and cord blood plasma samples were used for NMR-based metabolic fingerprinting and profiling, including analysis of the enrichment of circulating lipid classes and subclasses, as well as the number of sub-fraction particles and their size. Changes in phosphatidylcholines and glycoproteins were prominent in growth-restricted fetuses indicating significant alterations in their abundance and biophysical properties. Lipoprotein profiles showed significantly lower plasma concentrations of cholesterol-intermediate density lipoprotein (IDL), triglycerides-IDL and high-density lipoprotein (HDL) in mothers of growth-restricted fetuses compared to controls (p  10.1038/s41598-018-31832-5 2045-2322 Scientific reports http://hdl.handle.net/10668/12933 30206284 http://hdl.handle.net/20.500.12105/17629 Metabolic profiling and targeted lipidomics reveals a disturbed lipid profile in mothers and fetuses with intrauterine growth restriction.