2026-08-13T07:18:19Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/176172024-05-17T10:19:46Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud
author
Castellano-Castillo, Daniel
author
Moreno-Indias, Isabel
author
Fernández-García, José Carlos
author
Clemente-Postigo, Mercedes
author
Castro-Cabezas, Manuel
author
Tinahones, Francisco José
author
Queipo-Ortuño, María Isabel
author
Cardona, Fernando
2024-02-08T14:41:40Z
2024-02-08T14:41:40Z
2018-08-13
10.3390/genes9080410
2073-4425
Genes
http://hdl.handle.net/10668/12832
30104553
http://hdl.handle.net/20.500.12105/17617
Epigenetic marks, and especially DNA methylation, are becoming an important factor in obesity, which could help to explain its etiology and associated comorbidities. Adipose tissue, now considered as an important endocrine organ, produces complement system factors. Complement component 3 (C3) turns out to be an important protein in metabolic disorders, via either inflammation or the C3 subproduct acylation stimulating protein (ASP) which directly stimulates lipid storage. In this study, we analyze C3 DNA methylation in adipose tissue from subjects with a different grade of obesity. Adipose tissue samples were collected from subjects with a different degree of obesity determined by their body mass index (BMI) as: Overweight subjects (BMI ≥ 25 and
eng
ASP
C3
DNA methylation
Complement factor
Insulin resistance
Obesity
Complement Factor C3 Methylation and mRNA Expression Is Associated to BMI and Insulin Resistance in Obesity.
research article