2026-08-13T07:18:17Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/176172024-05-17T10:19:46Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927

00925njm 22002777a 4500 dc Castellano-Castillo, Daniel author Moreno-Indias, Isabel author Fernández-García, José Carlos author Clemente-Postigo, Mercedes author Castro-Cabezas, Manuel author Tinahones, Francisco José author Queipo-Ortuño, María Isabel author Cardona, Fernando author 2018-08-13 Epigenetic marks, and especially DNA methylation, are becoming an important factor in obesity, which could help to explain its etiology and associated comorbidities. Adipose tissue, now considered as an important endocrine organ, produces complement system factors. Complement component 3 (C3) turns out to be an important protein in metabolic disorders, via either inflammation or the C3 subproduct acylation stimulating protein (ASP) which directly stimulates lipid storage. In this study, we analyze C3 DNA methylation in adipose tissue from subjects with a different grade of obesity. Adipose tissue samples were collected from subjects with a different degree of obesity determined by their body mass index (BMI) as: Overweight subjects (BMI ≥ 25 and 10.3390/genes9080410 2073-4425 Genes http://hdl.handle.net/10668/12832 30104553 http://hdl.handle.net/20.500.12105/17617 ASP C3 DNA methylation Complement factor Insulin resistance Obesity Complement Factor C3 Methylation and mRNA Expression Is Associated to BMI and Insulin Resistance in Obesity.